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Validation of a mouse xenograft model system for gene expression analysis of human acute lymphoblastic leukaemia

Pre-clinical models that effectively recapitulate human disease are critical for expanding our knowledge of cancer biology and drug resistance mechanisms.

Authors:
Samuels AL, Peeva VK, Papa RA, Firth MJ, Francis RW, Beesley AH, Lock RB, Kees UR

Authors notes:
BMC Genomics. 2010 Apr 21;11:256.

Keywords:
validation, mouse xenograft model system, gene expression analysis, human acute lymphoblastic leukaemia

Abstract:
Pre-clinical models that effectively recapitulate human disease are critical for expanding our knowledge of cancer biology and drug resistance mechanisms.