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Ultraviolet irradiation of mice reduces the competency of bone marrow-derived CD11c+

Direct UV irradiation of dendritic cells and Langerhans cells reduces their Ag presenting ability. However, the effects of UV on CD11c(+) cells located...

Authors:
Ng RL, Bisley JL, Gorman S, Norval M, Hart PH

Authors notes:
J Immunol. 2010 Dec 15;185(12):7207-15. Epub 2010 Nov 15

Keywords:
Ultraviolet irradiation, mice, competency of bone marrow-derived CD11c+ cells, indomethacin-inhibitable pathway, UV

Abstract:
Direct UV irradiation of dendritic cells and Langerhans cells reduces their Ag presenting ability. However, the effects of UV on CD11c(+) cells located distally to the point of irradiation are poorly understood.