Lentivirus-mediated gene transfer of interleukin 10 to the ovine and human cornea

Gene transfer to a donor cornea ex vivo can modulate corneal graft failure in experimental animal models. We compared a lentiviral vector (LV) carrying...

Authors:
Parker DG, Coster DJ, Brereton HM, Hart PH, Koldej R, Anson DS, Williams KA.

Authors notes:
Clin Experiment Ophthalmol. 2010 May;38(4):405-13. Epub 2010 Feb 28.

Keywords:
lentivirus-mediated gene transfer, interleukin 10, ovine and human cornea

Abstract:
Gene transfer to a donor cornea ex vivo can modulate corneal graft failure in experimental animal models. We compared a lentiviral vector (LV) carrying the transgene ovine interleukin 10 (IL10) with a comparable adenoviral vector (Ad) for its ability to transduce ovine and human corneas and to modulate ovine corneal allograft survival.