UV inhibits allergic airways disease in mice by reducing effector CD4 T cells

In human asthma, and experimental allergic airways disease in mice, antigen-presenting cells and CD4(+) effector cells at the airway mucosa orchestrate, and CD4

Authors:
McGlade JP, Strickland DH, Lambert MJ, Gorman S, Thomas JA, Judge MA, Burchell JT, Zosky GR, Hart PH.

Authors notes:
Clin Exp Allergy. 2010 May;40(5):772-85. Epub 2010 Mar 4.

Keywords:
UV, inhibits allergic airways disease, mice, reducing effector CD4 T cells, human asthma, experimental allergic airways disease, antigen-presenting cells, asthma-like responses

Abstract:
n human asthma, and experimental allergic airways disease in mice, antigen-presenting cells and CD4(+) effector cells at the airway mucosa orchestrate, and CD4(+)CD25(+) regulatory T cells attenuate, allergen immunity. UV irradiation of skin before sensitization with ovalbumin (OVA) causes significantly reduced asthma-like responses in respiratory tissues.