Does genetic regulation of IgE begin in utero?

Elucidation of early life factors is critical to understand the development of allergic diseases, especially those manifesting in early life such as food allerg

Authors:
Hong X, Tsai HJ, Liu X, Arguelles L, Kumar R, Wang G, Kuptsova-Clarkson N, Pearson C, Ortiz K, Bonzagni A, Apollon S, Fu L, Pongracic JA, Schleimer R, Holt PG, Bauchner H, Wang X

Authors notes:
Journal of Allergy and Clinical Immunology 2010;126:1059-67 e1

Keywords:
genetic regulation, IgE, in utero, T(H)1/T(H)2 gene polymorphisms, cord blood total IgE

Abstract:
Elucidation of early life factors is critical to understand the development of allergic diseases, especially those manifesting in early life such as food allergies and atopic dermatitis. Cord blood IgE (CBIgE) is a recognized risk factor for the subsequent development of allergic diseases. In contrast with numerous genetic studies of total serum IgE in children and adults, limited genetic studies on CBIgE have been conducted.