Topical 1,25-dihydroxyvitamin D3 subverts the priming ability of draining lymph node dendritic cells

The active form of vitamin D, 1,25-hydroxyvitamin D(3) [1,25(OH)(2)D(3)] is produced in skin following exposure to sunlight

Authors:
Gorman S, Judge MA, Hart PH

Authors notes:
Immunology. 2010 Nov;131(3):415-25. doi:10.1111/j.1365-2567.2010.03315.x.

Keywords:
Topical 1,25-dihydroxyvitamin D3, priming ability, draining lymph node dendritic cells

Abstract:
The active form of vitamin D, 1,25-hydroxyvitamin D(3) [1,25(OH)(2)D(3)] is produced in skin following exposure to sunlight. It is also used topically to control inflammatory skin diseases by stimulating keratinocyte differentiation and suppressing immune responses.