Association of an allele on chromosome 9 and abdominal aortic aneurysm

Abdominal aortic aneurysm (AAA) has been recognized as a multi-factorial disease with both genetic and environmental risk factors.

Authors:
Biros E, Cooper M, Palmer LJ, Walker PJ, Norman PE, Golledge J

Authors notes:
Atherosclerosis 2010;212:539-42

Keywords:
allele, chromosome 9, abdominal aortic aneurysm

Abstract:
Abdominal aortic aneurysm (AAA) has been recognized as a multi-factorial disease with both genetic and environmental risk factors. A locus residing within non-coding DNA on chromosome 9p21.3 has recently been associated with AAA. To further investigate the significance of this site for AAA, we performed an association study on a large group of 3371 men aged 65-83 years of whom 513 had an AAA