Caudal dysgenesis and sirenomelia-single centre experience suggests common pathogenic basis

Abnormally formed lower limbs with varying degrees of fusion are the major feature of sirenomelia whereas maldeveloped lower limbs without fusion are found in a

Authors:
Thottungal AD, Charles AK, Dickinson JE, Bower C.

Authors notes:
Am J Med Genet A. 2010 Oct;152A(10):2578-87.

Keywords:
caudal dysgenesis, sirenomelia-single centre experience, common pathogenic basis, maldeveloped lower limbs

Abstract:
Abnormally formed lower limbs with varying degrees of fusion are the major feature of sirenomelia whereas maldeveloped lower limbs without fusion are found in association with caudal dysgenesis (CD). The relationship between these two entities has been a topic of debate for many years.