Gene regulation by 1,25-dihydroxyvitamin D3 in CD4+CD25+ cells is enabled by IL-2

Vitamin D may be responsible for reducing the development and severity of autoimmune and allergic diseases. Topically applied 1,25-dihydroxyvitamin D(3) (1,25(O

Authors:
Gorman S, Judge MA, Hart PH

Authors notes:
Journal of Investigative Dermatology 2010;130:2368-76

Keywords:
Gene regulation, 1,25-dihydroxyvitamin D3, CD4+CD25+ cells, enabled by IL-2

Abstract:
Vitamin D may be responsible for reducing the development and severity of autoimmune and allergic diseases. Topically applied 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) enhances the immunoregulatory ability of CD4+CD25+ T cells residing in the skin-draining lymph nodes (SDLNs) of mice.