Tumor Antigen Cross-Presentation and the Dendritic Cell: Where it All Begins?

Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that are critical for the generation of effective cytotoxic T lymphocyte (CTL) responses;

Authors:
McDonnell, A.M., Robnson, B.W.S. and Currie A.J

Authors notes:
Clin Dev Immunol. 2010;2010:539519. Epub 2010 Oct 13

Keywords:
Tumor Antigen Cross-Presentation, Dendritic Cell, Where it All Begins?, professional antigen-presenting cells, APCs, generation of effective cytotoxic T lymphoctye responses, CTL

Abstract:
Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that are critical for the generation of effective cytotoxic T lymphocyte (CTL) responses; however, their function and phenotype are often defective or altered in tumor-bearing hosts, which may limit their capacity to mount an effective tumor-specific CTL response