Authors:
R Booy, P Richmond, T Nolan, H Marshall, M Nissen, S Lambert, G Reynolds, J Ziegler, N. Mesaros, D Boutriau
Authors notes:
Pediatric Infectious Diseases Journal 2011; 30(4):340-2 (Impact factor 2.854)
Keywords:
immediate, longer term immunogenicity, safety of a single dose, combined haemophilus influenzae Type b-Neisseria meningitidis Serogroup C-Tetanus Toxoid Conjugate Vaccine in Hib-Primed Toddlers aged 12-18 Months
Abstract:
Hib-primed but MenC-naive toddlers (N = 433) were randomized to receive 1 dose of Hib-MenC-TT or separate Hib-TT and MenC-CRM197 vaccines. One month later, noninferiority was demonstrated for serum bactericidal anti-MenC antibodies (rSBA) and Hib antipolyribosylribitol phosphate (PRP) antibodies; >99% in both groups had rSBA titer ≥ 8 or anti-PRP concentration ≥ 0.15 μg/mL. After 12 months, rSBA titer ≥ 8 persisted in 86.7% and 76.4%, and anti-PRP concentration ≥ 0.15 μg/mL persisted in 98.8% and 100% of children, respectively