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Method of bacterial killing differentially affects the human innate immune response to Staphylococcus epidermidis

In vitro investigations of human innate immune responses to extracellular bacteria commonly utilise killed preparations in preference to live...

Authors:
Strunk T, Richmond P, Prosser A, Simmer K, Levy O, Burgner D, Currie A

Authors notes:
Innate Immunity 2011;17(6):508-16. Epub 2010 Aug 31. [Epub ahead of print] (Impact factor 2.206)

Keywords:
Method, bacterial killing differentially, affects the human innate immune response to Staphylococcus epidermidis

Abstract
In vitro investigations of human innate immune responses to extracellular bacteria commonly utilise killed preparations in preference to live organisms. The effects of the bacterial preparation method on the activation of innate signalling pathways by the common opportunistic pathogen Staphylococcus epidermidis (SE) are unknown.