Significant Association between Common Polymorphisms in the Aromatase Gene CYP19A1 and Bone Mineral Density in Postmenopausal Women

17β-Estradiol is important in maintaining bone structure, and regulation of its synthesis plays an important role in the development of postmenopausal...

Authors:
Mullin BH, Carter KW, Lewis JR, Ingley E, Wilson SG, Prince RL

Authors notes:
Calcified Tissue International Dec;89(6):464-71. doi: 10.1007/s00223-011-9535-8. Epub 2011 Sep 28

Keywords:
Significant Association, Common Polymorphisms, Aromatase Gene CYP19A1, Bone Mineral Density, Postmenopausal Women

Abstract
17β-Estradiol is important in maintaining bone structure, and regulation of its synthesis plays an important role in the development of postmenopausal osteoporosis. We and others have demonstrated associations between variation in the CYP19A1 gene (encoding aromatase) and areal bone mineral density (aBMD) phenotypes in women.