Authors:
Al-Tamimi, M.; Gardiner, E.E.; Thom, J.Y.;...; Cooper, M.N.; et al.
Authors notes:
Stroke. 2011 Feb;42(2):498-500
Keywords:
ischemic stroke, thrombosis, atherosclerotic plaque, collagen, platelet activation, glycoprotein VI
Abstract:
Ischemic stroke induced by thrombosis may be triggered by atherosclerotic plaque rupture and collagen-induced platelet activation. Collagen induces glycoprotein VI shedding.
We measured plasma-soluble glycoprotein VI (sGPVI) by enzyme-linked immunosorbent assay in 159 patients with acute (<7-day) ischemic stroke and age/sex-matched community-based control subjects.
sGPVI was elevated in stroke compared with controls (P=0.0168). ORs were higher in Quartile 4 for stroke cases (P=0.0121), and sGPVI was significantly elevated in stroke associated with large artery disease across Quartiles 2 to 4 and small artery disease in Quartile 4.
sGPVI decreased 3 to 6 months after antiplatelet treatment, consistent with elevated sGPVI due to platelet activation during the thrombotic event. sGPVI correlated with P-selectin (P=0.0007) and was higher in individuals with the GPVIa haplotype (P=0.024).
Glycoprotein VI shedding is implicated in the pathology of acute ischemic stroke.