Authors:
Bryant, K. A.; McVernon, J.; Marchant, C. D.; Nolan, T.; Marshall, G. S.; Richmond, P.; et al.
Authors notes:
Human Vaccines and Immunotherapeutics, 8(8), 1036-1041
Keywords:
Haemophilus influenzae type b, MMR, Neisseria meningitidis serogroups C and Y, Toddlers, Vaccination, Varicella
Abstract
A pooled analysis was conducted of 1,257 toddlers who received a fourth dose of Haemophilus influenzae type b- Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine (HibMenCY-TT) or Hib conjugate vaccine (Hib polysaccharide conjugated to N. meningitidis outer membrane protein) coadministered with measles-mumps-rubella (MMR) and varicella (VAR) vaccines (NCT00134719/NCT00289783).
Noninferiority of immunological responses to MMR and VAR was demonstrated between groups and incidences of MMR- and VAR-specific solicited symptoms were similar, indicating that HibMenCY-TT can be coadministered with MMR and VAR.