Do different glucose levels at calibration influence accuracy of continuous glucose monitoring readings in vitro?

The purpose of this study was to determine whether the accuracy of CGMs also improves if multiple calibrations are performed in vitro.

Authors:

Iscoe KE; Davey RJ; Fournier PA

Authors notes:

J Diabetes Sci Technol. [Letter]. 2012 Mar;6(2):477-478

Keywords:

Diabetes Glucose Monitoring Calibration

Abstract

The purpose of this study was to determine whether the intrinsic accuracy per se of CGMs also improves in the low glucose range if multiple calibrations are performed at different and low glucose concentrations in vitro.

The accuracy of the CGM tested here was influenced by the glucose level at which the last calibration was performed, thus corroborating, in part, the findings based on computer- based modeling.

However, given the evidence that CGM performance in vivo is poorer than in vitro, it remains to be tested whether calibration at different glucose levels might be even more beneficial in vivo than reported here in vitro.