Authors:
Larcombe AN; Zosky GR; Thamrin C; Bozanich EM; Hantos Z; Sly PD
Authors notes:
Influenza and other Respiratory Viruses. 2012:online
Keywords:
Constant-phase model, Forced oscillation technique, Influenza, Mouse, Severe lung disease
Abstract
The constant-phase model (CPM) is commonly fit to respiratory system input impedance (Z rs) to estimate lung mechanics.
Driving signal frequencies and the method of model fitting may influence the results, especially in cases of severe lung disease or under severe bronchoconstriction.
To illustrate the effects of different CPM fits to Z rs data using a mouse model of influenza-induced lung disease.
For influenza-infected mice, the unweighted fit was poor, and airway resistance (R aw) was often biologically impossible.
The weighted fit provided more realistic estimates of R aw. Different model fits and minimal frequencies had little effect on tissue mechanics