Authors:
Ripke S, O'Dushlaine C, Chambert K, Moran JL, Kähler AK, Akterin S, … Blackwell JM, et al.
Authors notes:
Nature Genetics. 2013;45(10):1150-1159
Keywords:
Schizophrenia, genome-wide association study, SNP, risk
Abstract:
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact.
We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-Analysis with previous schizophrenia GWAS (8,832 cases and 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls and 581 parent-offspring trios).
We identified 22 loci associated at genome-wide significance; 13 of these are new, and 1 was previously implicated in bipolar disorder.
Examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling.
We estimate that 8,300 independent, mostly common SNPs (95% credible interval of 6,300-10,200 SNPs) contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability.
Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder.