Authors:
Hollams EM, de Klerk NH, Holt PG, Sly PD
Authors notes:
American journal of respiratory and critical care medicine. 2013;189(4):401-407
Keywords:
Atopy, immune function, bronchial hyperresponsiveness, Raine study
Abstract:
The extent to which maternal smoking in pregnancy (MSP) has persisting effects on respiratory health remains uncertain and the mechanisms involved are not fully understood.
Alterations in immune function have has been proposed as a mechanism contributing to respiratory disease.
OUr objectives were to determine whether MSP increases risk of respiratory disorders in adolescence and, if so, whether this occurs via decreased lung function, altered immune function, and/or enhanced atopy.
MSP was reported for 21.0% (237/1129) of participants, with 92 (8.1%) reporting current smoking.
MSP was associated with some altered immune measures at age 14.
MSP was strongly related to reduced lung function in current non-smokers and increased risk for: current asthma; current wheeze; and exercise-induced wheeze, but not for BHR or atopy.
Adjustment for immune measures and/or lung function in multivariate models did not greatly alter these associations and the increased risks for asthma and wheeze were not modified by sex, atopy or maternal history of asthma or atopy.
Maternal smoking in pregnancy increases risk of asthma and wheezing in adolescence; mechanisms go beyond reducing lung function and exclude altering immune function or enhancing atopy.
Authors:
Hollams EM, de Klerk NH, Holt PG, Sly PD
Authors notes:
American journal of respiratory and critical care medicine. 2013;189(4):401-407
Keywords:
Atopy, immune function, bronchial hyperresponsiveness, Raine study
Abstract
The extent to which maternal smoking in pregnancy (MSP) has persisting effects on respiratory health remains uncertain and the mechanisms involved are not fully understood.
Alterations in immune function have has been proposed as a mechanism contributing to respiratory disease.
OUr objectives were to determine whether MSP increases risk of respiratory disorders in adolescence and, if so, whether this occurs via decreased lung function, altered immune function, and/or enhanced atopy.
MSP was reported for 21.0% (237/1129) of participants, with 92 (8.1%) reporting current smoking.
MSP was associated with some altered immune measures at age 14.
MSP was strongly related to reduced lung function in current non-smokers and increased risk for: current asthma; current wheeze; and exercise-induced wheeze, but not for BHR or atopy.
Adjustment for immune measures and/or lung function in multivariate models did not greatly alter these associations and the increased risks for asthma and wheeze were not modified by sex, atopy or maternal history of asthma or atopy.
Maternal smoking in pregnancy increases risk of asthma and wheezing in adolescence; mechanisms go beyond reducing lung function and exclude altering immune function or enhancing atopy.