Authors:
Weghofer M, Grote M, Resch Y, Casset A, Kneidinger M, Kopec J, Thomas WR, et al
Authors notes:
Journal of Immunology. 2013;190(7):3059-3067
Keywords:
Der p 23, house dust mite, allergen, peritrophin-like protein
Abstract:
The house dust mite (HDM) Dermatophagoides pteronyssinus is one of most important allergen sources and a major elicitor of allergic asthma.
We screened a D. pteronyssinus expression cDNA library with IgE Abs from HDM allergic patients.
Der p 23 represents a new major D. pteronyssinus allergen.
Furthermore, rDer p 23 exhibited high allergenic activity as demonstrated by upregulation of CD203c expression on basophils from D. pteronyssinus allergic patients.
Thus, we identified a new major D. pteronyssinus allergen as peritrophin-like protein.
The high allergenic activity of Der p 23 and its frequent recognition as respiratory allergen may be explained by the fact that it becomes airborne and respirable through its association with mite feces.
Der p 23 may be an essential component for diagnosis and specific immunotherapy of HDM allergy.