Authors:
Hansen M, Kurinczuk JJ, Milne E, de Klerk N, Bower C
Authors notes:
Human Reproduction Update. 2013;19(4):330-353
Keywords:
Assisted reproductive technology, Congenital malformations, IVF, Meta-analysis, Systematic review
Abstract:
It has been 10 years since we carried out a systematic search of the literature on birth defect risk in infants born following assisted reproductive technology (ART) compared with non-ART infants.
Because of changes to ART practice since that review and the publication of more studies the objective of this review was to include these more recent studies to estimate birth defect risk after ART and to examine birth defect risk separately in ART singletons and multiples.
There were 45 cohort studies included in this review.
ART infants had a higher risk of birth defects compared with naturally conceived infants.
The risk further increased when data were restricted to major birth defects or singletons only.
The results for ART multiples were less clear.
When all data for multiples were pooled the RR estimate was 1.11 but this increased to 1.26 when the analysis was restricted to studies of ART twins where some adjustment was made for differences in zygosity distribution between ART and non-ART multiples.
Birth defects remain more common in ART infants.
Further research is required to examine risks for important subgroups of ART exposure.