Authors:
Gunnell AS, Einarsdóttir K, Galvão DA, Joyce S, Tomlin S, Graham V, et al.
Authors notes:
PLoS ONE. 2013;8(10):e77833
Keywords:
Ischaemic heart disease, lifestyle factors, physical activity, smoking, hospitalisation
Abstract:
Lifestyle factors have been implicated in ischaemic heart disease (IHD) development however a limited number of longitudinal studies report results stratified by cardio-protective medication use.
This study investigated the influence of self-reported lifestyle factors on hospitalisation for IHD, stratified by blood pressure and/or lipid-lowering therapy.
Current smokers remained at higher risk for IHD-hospitalisation after adjustment for medication use, as did those considered overweight or obese.
Weekly leisure-time physical activity (LTPA) of 150 minutes or more and daily intake of 3 or more fruit/vegetable servings reduced risk by 21% and 26% respectively.
Benefits of LTPA appeared greatest in those on blood pressure lowering medication.
IHD risk in smokers was most pronounced in those taking neither medication.
This study confirms the contribution of previously reported lifestyle factors towards IHD hospitalisation, even after adjustment for antihypertensive and lipid-lowering medication use.
Medication stratified results suggest that IHD risks related to LTPA and smoking may differ according to medication use.