Authors:
Barraza-Villarreal A, Escamilla-Nuñez MC, Schilmann A, Hernandez-Cadena L,..., Sly P, Romieu I
Authors notes:
Journal of Occupational and Environmental Medicine 56(4): 415-419.
Keywords:
2 fluorenol, fluorene, polycyclic aromatic hydrocarbon, unclassified drug, article, child, environmental exposure, exhalation, female, forced expiratory volume, human, lung function, major clinical study, male, Mexico, pH, pilot study, respiratory tract inflammation, school child, urinalysis
Abstract:
To determine the association of exposure to polycyclic aromatic hydrocarbons (PAHs) with lung function and pH of exhaled breath condensate (EBC) in Mexican schoolchildren, a pilot study was performed in a subsample of 64 schoolchildren from Mexico City.
Lung function and pH of EBC were measured and metabolites of PAHs in urine samples were determined.
The association was analyzed using robust regression models.
A 10% increase in the concentrations of 2-hydroxyfluorene was significantly negatively associated with forced expiratory volume in 1 second, forced vital capacity, and pH of EBC.
Biomarkers of PAHs exposure were inversely associated with lung function and decrease of pH of EBC as a marker of airway inflammation in Mexican school children.