Authors:
Bailey HD, Fritschi L, Metayer C, Infante-Rivard C, Magnani C, Petridou E, ... Milne E, et al.
Authors notes:
Cancer Causes and Control. 2014;25(10):1351-1367
Keywords:
Paint, parental occupation, leukemia, childhood, pooled analysis, meta-analysis
Abstract:
It has been suggested that parental occupational paint exposure around the time of conception or pregnancy increases the risk of childhood leukemia in the offspring.
Using individual data from fathers of 8,185 cases and 14,210 controls, the pooled OR for paternal exposure around conception and risk of acute lymphoblastic leukemia (ALL) was 0.93.
Analysis of data from 8,156 ALL case mothers and 14,568 control mothers produced a pooled OR of 0.81 for exposure during pregnancy.
For acute myeloid leukemia (AML), the pooled ORs for paternal and maternal exposure were 0.96 and 1.31, respectively, based on data from 1,231 case and 11,392 control fathers and 1,329 case and 12,141 control mothers.
Heterogeneity among the individual studies ranged from low to modest.
Null findings for paternal exposure for both ALL and AML are consistent with previous reports.
Despite the large sample size, results for maternal exposure to paints in pregnancy were based on small numbers of exposed.
Overall, we found no evidence that parental occupational exposure to paints increases the risk of leukemia in the offspring, but further data on home exposure are needed.