Authors:
Minney-Smith CA, Levy A, Hodge M, Jacoby P, Williams SH, Carcione D, et al.
Authors notes:
Journal of Clinical Virology. 2014;61:579-584
Keywords:
Adenovirus, Enterovirus, Intussusception, Rotavirus
Abstract:
Intussusception, a condition where one segment of intestine invaginates into another, occurs predominantly in infants and young children.
A number of potential causes have been identified including infectious agents and rotavirus vaccination.
Following the introduction of rotavirus vaccination of infants in Western Australia, a laboratory surveillance programme testing notified intussusception cases for infectious agents was commenced.
This led to a PCR-based study of the association between gastrointestinal viruses and intussusception.
Our objectives were to conduct viral testing on stool samples from intussusception patients to determine viruses that may have an association with intussusception.
Human adenovirus C was detected in significantly more cases than controls with 31/74 (41.9%) cases testing positive compared to 39/289 (13.49%) controls.
A significant difference was seen in Enterovirus B detections with 11/74 (14.9%) cases testing positive compared to 21/289 (7.3%) controls.
Rotavirus was detected in 7/74 (9.46%) cases and 11/289 (3.81%) controls, which was also a significant difference.
Our results show that intussusception is associated with non-enteric adenovirus infections, and Enterovirus B infections.
While a statistical association was seen with rotavirus and intussusception, we were not able to determine if this was related to vaccine strain or wild type rotavirus.