Authors:
Jones AP, D'Vaz N, Meldrum S, Palmer DJ, Zhang G, Prescott SL
Authors notes:
Clinical and Experimental Allergy. 2014;45(1):220-231
Keywords:
25(OH)D3, Allergens, Allergic disease, Cord blood, Cytokines, Eczema, Toll-like receptor, Vitamin D
Abstract:
Vitamin D (25[OH]D3) status in early life has been linked to the risk of allergic disease in multiple observational studies.
While immunomodulating properties are well recognized, there are few longitudinal studies of 25(OH)D3 status, immune function and allergic disease in infants.
Our objective was to investigate 25(OH)D3 levels at birth [cord blood (CB)] and at 6 months of age in relation to immune function at 6 months of age, and clinical outcomes up to 30 months of age in infants with a maternal history of atopy.
Infants with higher 25(OH)D3 at birth (≥ 75 nmol/L, compared with < 50 nmol/L) had lower IL-5 and IL-13 responses to HDM by 6 months.
This was also reflected in strong inverse correlations between CB 25(OH)D3 levels and HDM IL-13 and IL-5 responses, with a similar trend for IL-5 responses to OVA.
For innate stimulations, higher 25(OH)D3 levels at 6 months were associated with greater responses to TLR ligands.
Additionally, higher CB 25(OH)D3 was associated with reduced risk eczema at 6 months and 12 months.
This suggests that improving 25(OH)D3 status in pregnancy or early infancy may reduce the development of allergic disease in high-risk infants by inhibiting cytokine profiles associated with allergy.
Results of clinical trials are awaited to determine the efficacy of vitamin D supplementation in allergy prevention.