Authors:
Cho YH, Craig ME, Davis EA, Cotterill AM, Couper JJ, Cameron FJ, Benitez-Aguirre PZ, Dalton RN, Dunger DB, Jones TW, Donaghue KC
Authors notes:
Diabetes Care. 2015;38(4):676-681
Keywords:
Cardiac autonomic dysfunction, albumin-to-creatinine ratio, adolescents, type 1 diabetes, nephropathy
Abstract:
This study examined the association between cardiac autonomic dysfunction and high albumin-to-creatinine ratio (ACR) in adolescents with type 1 diabetes.
The upper-tertile ACR group had a faster heart rate and less heart rate variability.
HbA1c was 8.5% (69 mmol/mmol) in the upper tertile vs. 8.3% (67 mmol/mol) in the lower tertiles.
In multivariable analysis, upper-tertile ACR was associated with faster heart rate and lower RMSSD, independent of age and HbA1c.
Adolescents at potentially higher risk for nephropathy show an adverse cardiac autonomic profile, indicating sympathetic overdrive, compared with the lower-risk group.
Longitudinal follow-up of this cohort will further characterize the relationship between autonomic and renal dysfunction and the effect of interventions in this population.