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Impaired airway epithelial cell responses from children with asthma to rhinoviral infection

Human rhinovirus infection delays repair and inhibits apoptotic processes in epithelial cells from non-asthmatic and asthmatic children

Citation:
Kicic A, Stevens PT, Sutanto EN, Kicic-Starcevich E, Ling KM, Looi K, Martinovich KM, Garratt LW, Iosifidis T, Shaw NC, ... Stick SM. Impaired airway epithelial cell responses from children with asthma to rhinoviral infection. Clinical and Experimental Allergy. 2016;46(11):1441-55

Keywords:
airway epithelium; asthma; human rhinovirus; wound repair

Abstract:
The airway epithelium forms an effective immune and physical barrier that is essential for protecting the lung from potentially harmful inhaled stimuli including viruses. Human rhinovirus (HRV) infection is a known trigger of asthma exacerbations, although the mechanism by which this occurs is not fully understood.