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Minimal structural lung disease in early life represents significant pathology

In this cohort, as compared with the AREST CF cohort, the authors highlight the limited correlation between infection and inflammation with lung function and structural impairment, and that this was mainly explained by the mild changes identified in lung function and on chest CT scan.

Citation:
Shanthikumar S, Stick SM, Ranganathan SC. Minimal structural lung disease in early life represents significant pathology. J Cyst Fibros. 2020.

Keywords:
Cystic fibrosis; lung disease; PRAGMA CT score

Abstract:
In this cohort, as compared with the AREST CF cohort, the authors highlight the limited correlation between infection and inflammation with lung function and structural impairment, and that this was mainly explained by the mild changes identified in lung function and on chest CT scan.