Citation:
Madhi SA, Polack FP, Piedra PA, Munoz FM, Trenholme AA, ...... Richmond PC, ....... Stoney T, et al. Respiratory Syncytial Virus Vaccination during Pregnancy and Effects in Infants. N Engl J Med. 2020;383(5):426-39.
Keywords:
Respiratory syncytial virus, efficacy, pregnancy, pneumonia, newborns, infants, phase III trial, immunogenicity, safety, epidemiology, transplacental antibody transfer
Abstract:
A multi-country randomized, placebo-controlled trial of the safety, immunogenicity and efficacy of respiratory syncytial virus (RSV) F-protein nanoparticle vaccine was undertaken in 4,636 pregnant women and their infants. RSV F-protein vaccine was safe and immunogenic in the pregnant women inducing anti-F IgG, palivizumab-competing antibodies and RSV neutralizing antibodies that were transferred to the fetus.