Citation:
Sinha A, Saleh A, Endersby R, Yuan SH, Chokshi CR, Brown KR, et al. RAD51-Mediated DNA Homologous Recombination Is Independent of PTEN Mutational Status. Cancers (Basel). 2020;12(11):1-22.
Keywords:
DNA damage; Hrd; PARP inhibitor; Pten; Rad51; RAD51 foci; RNA expression; alkaline comet assay; base excision repair; brain tumor initiating cells; combination therapy; glioblastoma multiforme; homologous recombination; olaparib; synthetic lethality; gammaH2AX foci
Abstract:
PTEN mutation occurs in a variety of aggressive cancers and is associated with poor patient outcomes. Recent studies have linked mutational loss of PTEN to reduced RAD51 expression and function, a key factor involved in the homologous recombination (HR) pathway. However, these studies remain controversial, as they fail to establish a definitive causal link to RAD51 expression that is PTEN-dependent, while other studies have not been able to recapitulate the relationship between the PTEN expression and the RAD51/HR function.
RAD51-Mediated DNA Homologous Recombination Is Independent of PTEN Mutational Status
PTEN mutation occurs in a variety of aggressive cancers and is associated with poor patient outcomes. Recent studies have linked mutational loss of PTEN to reduced RAD51 expression and function, a key factor involved in the homologous recombination (HR) pathway. However, these studies remain controversial, as they fail to establish a definitive causal link to RAD51 expression that is PTEN-dependent, while other studies have not been able to recapitulate the relationship between the PTEN expression and the RAD51/HR function.