Citation:
Orami T, Ford R, Kirkham LA, Thornton R, Corscadden K, Richmond PC, Pomat WS van den Biggelaar AHJ, Lehmann D. Pneumococcal conjugate vaccine primes mucosal immune responses to pneumococcal polysaccharide vaccine booster in Papua New Guinean children. Vaccine. 2020;38(50):7977-88.
Keywords:
Children; IgA; IgG; Immune memory; Mucosal immunity; Papua New Guinea; Pneumococcal conjugate vaccine; Pneumococcal polysaccharide vaccine; Pneumococci; Pneumonia; Salivary antibodies.
Abstract:
Invasive pneumococcal disease remains a major cause of hospitalization and death in Papua New Guinean (PNG) children. We assessed mucosal IgA and IgG responses in PNG infants vaccinated with pneumococcal conjugate vaccine (PCV) followed by a pneumococcal polysaccharide vaccine (PPV) booster.
Pneumococcal conjugate vaccine primes mucosal immune responses to pneumococcal polysaccharide vaccine booster in Papua New Guinean children
Invasive pneumococcal disease remains a major cause of hospitalization and death in Papua New Guinean (PNG) children. We assessed mucosal IgA and IgG responses in PNG infants vaccinated with pneumococcal conjugate vaccine (PCV) followed by a pneumococcal polysaccharide vaccine (PPV) booster.