The Kids Research Institute Australia logo
Donate

Discover Prevent Cure

Veliparib Is an Effective Radiosensitizing Agent in a Preclinical Model of Medulloblastoma

Medulloblastoma is the most common malignant childhood brain tumor, and 5-year overall survival rates are as low as 40% depending on molecular subtype, with new therapies critically important. As radiotherapy and chemotherapy act through the induction of DNA damage, the sensitization of cancer cells through the inhibition of DNA damage repair pathways is a potential therapeutic strategy.

Citation:
Buck J, Dyer PJC, Hii H, Carline B, Kuchibhotla M, Byrne J, Howlett M, Whitehouse J, Ebert MA, McDonald KL, Gottardo NG, Endersby R. Veliparib Is an Effective Radiosensitizing Agent in a Preclinical Model of Medulloblastoma. Front Mol Biosci. 2021;8.

Keywords:
DNA repair; Medulloblastoma; poly(ADP-ribose) polymerase; radiotherapy; veliparib

Abstract:
Medulloblastoma is the most common malignant childhood brain tumor, and 5-year overall survival rates are as low as 40% depending on molecular subtype, with new therapies critically important. As radiotherapy and chemotherapy act through the induction of DNA damage, the sensitization of cancer cells through the inhibition of DNA damage repair pathways is a potential therapeutic strategy.