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The longitudinal relationship between BOLD signal variability changes and white matter maturation during early childhood

Intra-individual transient temporal fluctuations in brain signal, as measured by fMRI blood oxygenation level dependent (BOLD) variability, is increasingly considered an important signal rather than measurement noise.

Citation:
Wang H, Ghaderi A, Long X, Reynolds JE, Lebel C, Protzner AB. The longitudinal relationship between BOLD signal variability changes and white matter maturation during early childhood. NeuroImage. 2021;242.

Keywords:
BOLD signal variability; Brain development; Early childhood; Longitudinal; Structure-function relationship; White matter

Abstract:
Intra-individual transient temporal fluctuations in brain signal, as measured by fMRI blood oxygenation level dependent (BOLD) variability, is increasingly considered an important signal rather than measurement noise. Evidence from computational and cognitive neuroscience suggests that signal variability is a good proxy-measure of brain functional integrity and information processing capacity.