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Previous Influenza Infection Exacerbates Allergen Specific Response and Impairs Airway Barrier Integrity in Pre-Sensitized Mice

In this study we assessed the effects of antigen exposure in mice pre‐sensitized with allergen following viral infection on changes in lung function, cellular responses and tight junction expression.

Citation:
Looi K, Larcombe AN, Perks KL, Berry LJ, Zosky GR, Rigby P, Kicic A, Stick SM. Previous influenza infection exacerbates allergen specific response and impairs airway barrier integrity in pre‐sensitized mice. Int J Mol Sci. 2021;22(16).

Keywords:
BALB/c mice; Epithelial barrier integrity; House dust mite; Influenza; Lung function;
Tight junctions

Abstract:
In this study we assessed the effects of antigen exposure in mice pre‐sensitized with allergen following viral infection on changes in lung function, cellular responses and tight junction expression.