Characterization of the transient deficiency of pkc isozyme levels in immature cord blood t cells and its connection to anti‐allergic cytokine profiles of the matured cells

Cord blood T cells (CBTC) from a proportion of newborns express low/deficient levels of some protein kinase C (PKC) isozymes, with low levels of PKCζ correlating with increased risk of developing allergy and associated decrease in interferon‐gamma (IFN‐γ) producing T cells.

Citation:
Perveen K, Quach A, Stark MJ, Prescott SL, Barry SC, Hii CS, et al. Characterization of the transient deficiency of pkc isozyme levels in immature cord blood t cells and its connection to anti‐allergic cytokine profiles of the matured cells. Int J Mol Sci. 2021;22(23).

Keywords:
Allergy; CD4+ and CD8+ T cells; Cord blood T cells; Cytokines; Neonate; PKC isozymes; PKCζ; T cell maturation; Th1 and Th2/9 subsets

Abstract:
Cord blood T cells (CBTC) from a proportion of newborns express low/deficient levels of some protein kinase C (PKC) isozymes, with low levels of PKCζ correlating with increased risk of developing allergy and associated decrease in interferon‐gamma (IFN‐γ) producing T cells.