Personal network inference unveils heterogeneous immune response patterns to viral infection in children with acute wheezing

Human rhinovirus (RV)-induced exacerbations of asthma and wheeze are a major cause of emergency room presentations and hospital admissions among children. Previous studies have shown that immune response patterns during these exacerbations are heterogeneous and are characterized by the presence or absence of robust interferon responses.

Citation:
Coleman LA, Khoo SK, Franks K, Prastanti F, Le Souëf P, Karpievitch YV, Laing IA, Bosco A. Personal network inference unveils heterogeneous immune response patterns to viral infection in children with acute wheezing. J Pers Med. 2021;11(12).

Keywords:
Acute asthma; aeroallergen; allergen; corticosteroid;
unclassified drug; acute disease; asthma; atopy; bronchiolitis; cohort analysis; controlled study; gene expression; immune response; major clinical study; virus infection; wheezing

Abstract:
Human rhinovirus (RV)-induced exacerbations of asthma and wheeze are a major cause of emergency room presentations and hospital admissions among children. Previous studies have shown that immune response patterns during these exacerbations are heterogeneous and are characterized by the presence or absence of robust interferon responses.