Citation:
Huang RC, Melton PE, Burton MA, Beilin LJ, ..... Anderson D, Rauschert S, Craig JM et al. Adiposity associated DNA methylation signatures in adolescents are related to leptin and perinatal factors. Epigenetics. 2021.
Keywords:
DNA methylation; adiposity; adolescence; body Composition; body mass index; epigenetic Variation; high-sensitivity C-reactive Protein; inflammation; leptin; maternal; the Raine Study; youth
Abstract:
Epigenetics links perinatal influences with later obesity. We identifed differentially methylated CpG (dmCpG) loci measured at 17 years associated with concurrent adiposity measures and examined whether these were associated with hsCRP, adipokines, and early life environmental factors. Genome-wide DNA methylation from 1192 Raine Study participants at 17 years, identified 29 dmCpGs associated with body mass index, 10 with waist circumference and 9 with subcutaneous fat thickness.
Adiposity associated DNA methylation signatures in adolescents are related to leptin and perinatal factors
Epigenetics links perinatal influences with later obesity. We identifed differentially methylated CpG (dmCpG) loci measured at 17 years associated with concurrent adiposity measures and examined whether these were associated with hsCRP, adipokines, and early life environmental factors. Genome-wide DNA methylation from 1192 Raine Study participants at 17 years, identified 29 dmCpGs associated with body mass index, 10 with waist circumference and 9 with subcutaneous fat thickness.