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Autoantibodies and cancer among asbestos-exposed cohorts in Western Australia

Asbestos exposure is associated with many adverse health conditions including malignant mesothelioma and lung cancer as well as production of autoantibodies. Autoantibodies may serve as biomarkers for asbestos exposure in patients with cancer, and autoimmune dysfunction has been linked to increased rates of various cancers. The aim of this study was to examine the hypothesis that autoantibodies are more frequent in asbestos-exposed individuals with either lung cancer or mesothelioma than those without these conditions.

Citation:
Carey RN, Pfau JC, Fritzler MJ, Creaney J, de Klerk N, W Musk A, et al. Autoantibodies and cancer among asbestos-exposed cohorts in Western Australia. J Toxicol Environ Health Part A Curr Iss. 2021.     

Keywords:
Asbestos; autoimmune antibodies; cancer; exposure; lung cancer; malignant mesothelioma

Abstract:
Asbestos exposure is associated with many adverse health conditions including malignant mesothelioma and lung cancer as well as production of autoantibodies. Autoantibodies may serve as biomarkers for asbestos exposure in patients with cancer, and autoimmune dysfunction has been linked to increased rates of various cancers. The aim of this study was to examine the hypothesis that autoantibodies are more frequent in asbestos-exposed individuals with either lung cancer or mesothelioma than those without these conditions.