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PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum

Large-scale molecular profiling studies in recent years have shown that central nervous system (CNS) tumors display a much greater heterogeneity in terms of molecularly distinct entities, cellular origins and genetic drivers than anticipated from histological assessment.

Citation:
Alhalabi KT, Stichel D, Sievers P, Peterziel H, …….. Gottardo N, Uro-Coste E, et al. PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum. Acta Neuropathol. 2021;142(5):841-57.

Keywords:
Brain tumor; ewsr1; Gene fusion; mn1; Neuroepithelial; Neurooncology;
patz1; Pediatric

Abstract:
Large-scale molecular profiling studies in recent years have shown that central nervous system (CNS) tumors display a much greater heterogeneity in terms of molecularly distinct entities, cellular origins and genetic drivers than anticipated from histological assessment.