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Challenges in the Management of Childhood Intracranial Germ Cell Tumors in Middle-Income Countries: A 20-Year Retrospective Review From a Single Tertiary Center in Malaysia

A higher incidence of pediatric intracranial germ cell tumors (iGCTs) in Asian countries compared with Western countries has been reported. In Malaysia, the literature regarding pediatric iGCTs have been nonexistent. The aim of this study was to review the management, survival, and long-term outcomes of pediatric iGCTs at a single tertiary center in Malaysia.

Citation:
Rajagopal R, Leong SH, Jawin V, Foo JC, …… Gottardo NG, Bouffet E, et al. Challenges in the Management of Childhood Intracranial Germ Cell Tumors in Middle-Income Countries: A 20-Year Retrospective Review From a Single Tertiary Center in Malaysia. J Pediatr Hematol Oncol. 2021;43(7):e913-e23.

Keywords:
Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Brain Neoplasms/epidemiology/pathology; Combined Modality Therapy; Developing Countries; Disease Management;
Follow-Up Studies; Malaysia; Quality of Life; Retrospective Studies

Abstract:
A higher incidence of pediatric intracranial germ cell tumors (iGCTs) in Asian countries compared with Western countries has been reported. In Malaysia, the literature regarding pediatric iGCTs have been nonexistent. The aim of this study was to review the management, survival, and long-term outcomes of pediatric iGCTs at a single tertiary center in Malaysia.