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Off-target effects of bacillus Calmette-Guerin vaccination on immune responses to SARS-CoV-2: implications for protection against severe COVID-19

Because of its beneficial off-target effects against non-mycobacterial infectious diseases, bacillus Calmette-Guérin vaccination might be an accessible early intervention to boost protection against novel pathogens. Multiple epidemiological studies and randomised controlled trials are investigating the protective effect of BCG against coronavirus disease 2019 (COVID-19).

Citation:
Messina NL, Germano S, McElroy R, …….Curtis N. (Amenyogbe N, Benothman R, Eiffler N, Kollmann T, Manning L, McAlister S, O’Donnell M, Parkin K, Perez G, Richmond P, Wadia U, Jones J, Jones J, Kent J, Jones K, et al for the BRACE Trial). Off-target effects of bacillus Calmette-Guerin vaccination on immune responses to SARS-CoV-2: implications for protection against severe COVID-19. Clin Transl Immunology. 2022;11(4):e1387.

Keywords:
BCG; COVID‐19; SARS‐CoV‐2; T cell; cytokine; immunoregulation

Abstract:
Because of its beneficial off-target effects against non-mycobacterial infectious diseases, bacillus Calmette-Guérin vaccination might be an accessible early intervention to boost protection against novel pathogens. Multiple epidemiological studies and randomised controlled trials are investigating the protective effect of BCG against coronavirus disease 2019 (COVID-19).