The Kids Research Institute Australia logo
Donate

Discover Prevent Cure

Retinoic Acid Induces an IFN-Driven Inflammatory Tumour Microenvironment, Sensitizing to Immune Checkpoint Therapy

With immune checkpoint therapy (ICT) having reshaped the treatment of many cancers, the next frontier is to identify and develop novel combination therapies to improve efficacy. Previously, we and others identified beneficial immunological effects of the vitamin A derivative tretinoin on anti-tumour immunity.

Citation:
Tilsed CM, Casey TH, de Jong E, Bosco A, Zemek RM, …….. Lesterhuis WJ. Retinoic Acid Induces an IFN-Driven Inflammatory Tumour Microenvironment, Sensitizing to Immune Checkpoint Therapy. Front Oncol. 2022;12.

Keywords:
Cancer; immune checkpoint therapy; interferon; mesothelioma; retinoic acid; gamma interferon; cell infiltration; immune response; RNA sequence; T cell lymphoma; tumor growth; tumor immunity; tumor microenvironment

Abstract:
With immune checkpoint therapy (ICT) having reshaped the treatment of many cancers, the next frontier is to identify and develop novel combination therapies to improve efficacy. Previously, we and others identified beneficial immunological effects of the vitamin A derivative tretinoin on anti-tumour immunity.