Frankenstein Cas9: engineering improved gene editing systems

The discovery of CRISPR-Cas9 and its widespread use has revolutionised and propelled research in biological sciences.

Citation:
Vos PD, Filipovska A, Rackham O. Frankenstein Cas9: engineering improved gene editing systems. Biochem Soc Trans. 2022;50(5):1505-16.

Keywords:
CRISPR; designer Cas9; enzyme design; gene editing; protein engineering; synthetic biology

Abstract:
The discovery of CRISPR-Cas9 and its widespread use has revolutionised and propelled research in biological sciences.