Identification of distinct functional thymic programming of fetal and pediatric human γδ thymocytes via single-cell analysis

Developmental thymic waves of innate-like and adaptive-like γδ T cells have been described, but the current understanding of γδ T cell development is mainly limited to mouse models.

Citation:
Sanchez Sanchez G, Papadopoulou M, …….. Mishra A, Chan JKY, Fan Y, et al. Identification of distinct functional thymic programming of fetal and pediatric human γδ thymocytes via single-cell analysis. Nature Communications. 2022;13(1)

Keywords:
Lymphocyte antigen receptor; RNA; cell differentiation; genetics; metabolism; single cell analysis; T lymphocyte subpopulation; thymocyte; thymus; Receptors, Antigen, T-Cell, gamma-delta

Abstract:
Developmental thymic waves of innate-like and adaptive-like γδ T cells have been described, but the current understanding of γδ T cell development is mainly limited to mouse models.