The effect of CFTR modulators on structural lung disease in cystic fibrosis

Newly developed quantitative chest computed tomography (CT) outcomes designed specifically to assess structural abnormalities related to cystic fibrosis (CF) lung disease are now available. CFTR modulators potentially can reduce some structural lung abnormalities. We aimed to investigate the effect of CFTR modulators on structural lung disease progression using different quantitative CT analysis methods specific for people with CF (PwCF).

Citation:
Mok LC, Garcia-Uceda A, Cooper MN, Kemner-Van De Corput M, ……. Rosenow T, De Boeck K, Stick S, Tiddens HAWM. The effect of CFTR modulators on structural lung disease in cystic fibrosis. Front Pharmacol. 2023;14

Keywords:
CFTR modulator; chest CT; cystic fibrosis; quantitative measures; structural lung disease

Abstract:
Newly developed quantitative chest computed tomography (CT) outcomes designed specifically to assess structural abnormalities related to cystic fibrosis (CF) lung disease are now available. CFTR modulators potentially can reduce some structural lung abnormalities. We aimed to investigate the effect of CFTR modulators on structural lung disease progression using different quantitative CT analysis methods specific for people with CF (PwCF).