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Inhaled corticosteroids to improve lung function in children (aged 6–12 years) who were born very preterm (PICSI): a randomised, double-blind, placebo-controlled trial

Despite the substantial burden of lung disease throughout childhood in children who were born very preterm, there are no evidence-based interventions to improve lung health beyond the neonatal period. We tested the hypothesis that inhaled corticosteroid improves lung function in this population.

Citation:
Urs RC, Evans DJ, Bradshaw TK, Gibbons JTD, Smith EF, Foong RE, Wilson AC, Simpson SJ. Inhaled corticosteroids to improve lung function in children (aged 6–12 years) who were born very preterm (PICSI): a randomised, double-blind, placebo-controlled trial. Lancet Child Adolesc Health. 2023;7(8):567-76

Keywords:
Adrenal cortex hormomes; epidemiology; bronchodilator agents; Covid-19; fluticasone; infants; premature birth; lungs; therapeutic use

Abstract:
Despite the substantial burden of lung disease throughout childhood in children who were born very preterm, there are no evidence-based interventions to improve lung health beyond the neonatal period. We tested the hypothesis that inhaled corticosteroid improves lung function in this population.