Genetic variants of TLR4, including the novel variant, rs5030719, and related genes are associated with susceptibility to clinical malaria in African children

Malaria is a deadly disease caused by Plasmodium spp. Several blood phenotypes have been associated with malarial resistance, which suggests a genetic component to immune protection.

Citation:
Ariff A, Song Y, Aguilar R, …… Khoo SK, Wiertsema S, Bassat Q, …… Laing IA, Guinovart C, ……. Le Souëf P, Zhang G. Genetic variants of TLR4, including the novel variant, rs5030719, and related genes are associated with susceptibility to clinical malaria in African children. Malar J. 2023;22(1)

Keywords:
Africa; Genetic polymorphisms; Haplotype trend regression; Malaria; TLR4; rs5030719

Abstract:
Malaria is a deadly disease caused by Plasmodium spp. Several blood phenotypes have been associated with malarial resistance, which suggests a genetic component to immune protection.