Increasing airway obstruction through life following bronchopulmonary dysplasia: a meta-analysis

Few studies exist investigating lung function trajectories of those born preterm; however growing evidence suggests some individuals experience increasing airway obstruction throughout life. Here we use the studies identified in a recent systematic review to provide the first meta-analysis investigating the impact of preterm birth on airway obstruction measured by the forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) ratio.

Citation:
Gibbons JTD, Course CW, Kotecha SJ, Simpson SJ, Evans EE, Kotecha S. Increasing airway obstruction through life following bronchopulmonary dysplasia: a meta-analysis. ERJ Open Res. 2023;9(3)

Keywords:
Pre-term birth; airway obstruction; lung function; systematic review; forced expiratory volume

Abstract:
Few studies exist investigating lung function trajectories of those born preterm; however growing evidence suggests some individuals experience increasing airway obstruction throughout life. Here we use the studies identified in a recent systematic review to provide the first meta-analysis investigating the impact of preterm birth on airway obstruction measured by the forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) ratio.