Molecular basis of translation termination at noncanonical stop codons in human mitochondria

The genetic code that specifies the identity of amino acids incorporated into proteins during protein synthesis is almost universally conserved. Mitochondrial genomes feature deviations from the standard genetic code, including the reassignment of two arginine codons to stop codons.

Citation:
Saurer M, Leibundgut M, Nadimpalli HP, ……. Rackham O, Dreos R, …… Filipovska A, Ban N. Molecular basis of translation termination at noncanonical stop codons in human mitochondria. Science. 2023;380(6644):531-6.

Abstract:
The genetic code that specifies the identity of amino acids incorporated into proteins during protein synthesis is almost universally conserved. Mitochondrial genomes feature deviations from the standard genetic code, including the reassignment of two arginine codons to stop codons.